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Article

Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.

Autophagy - 2 Oct 2016

Kim Dong-Kyu, Lim Hee-Sun, Kawasaki Ichiro, Shim Yhong-Hee, Vaikath Nishant N, El-Agnaf Omar M A, Lee He-Jin, Lee Seung-Jae

Abstract excerpt

Aging is the major risk factor for neurodegenerative diseases that are also associated with impaired proteostasis, resulting in abnormal accumulation of protein aggregates. However, the role of aging in development and progression of disease remains elusive. Here, we used Caenorhabditis elegans models to show that aging-promoting genetic variations accelerated the rate of cell-to-cell transmission of...

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Identifiers

PMID: 27485532
DOI: 10.1080/15548627.2016.1207014
PMCID: PMC5079673

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SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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