Article

Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer's Disease, and Apolipoprotein E- 4/4 Genotype

1999-01-01

Abstract excerpt

Sleep disruption, nightly restlessness, sundowning, and other circadian disturbances are frequently seen in Alzheimer's disease (AD) patients. Changes in the suprachiasmatic nucleus and pineal gland are thought to be the biological basis for these behavioral disturbances. Melatonin is the main endocrine message for circadian rhythmicity from the pineal. To determine whether melatonin production was affected in AD,...

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Literature Corpus work: 66854114-c4f0-591f-aeab-f393d34fb8f1
DOI: 10.1210/jc.84.1.323

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