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Melatonin receptor type 1A gene linked to Alzheimer's disease in old age.

Sleep - 1 Jul 2018

Sulkava Sonja, Muggalla Pranuthi, Sulkava Raimo, Ollila Hanna M, Peuralinna Terhi, Myllykangas Liisa, Kaivola Karri, Stone David J, Traynor Bryan J, Renton Alan E, Rivera Alberto M, Helisalmi Seppo, Soininen Hilkka, Polvikoski Tuomo, Hiltunen Mikko, Tienari Pentti J, Huttunen Henri J, Paunio Tiina

Abstract excerpt

Disruption of the circadian rhythms is a frequent preclinical and clinical manifestation of Alzheimer's disease. Furthermore, it has been suggested that shift work is a risk factor for Alzheimer's disease. Previously, we have reported association of intolerance to shift work (job-related exhaustion in shift workers) with a variant rs12506228A, which is situated close to melatonin receptor type 1A gene (MTNR1A)...

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Identifiers

PMID: 29982836
DOI: 10.1093/sleep/zsy103
PMCID: PMC6047434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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