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Article

Chronic ramelteon treatment in a mouse model of Alzheimer's disease.

Archives italiennes de biologie - 1 Mar 2012

McKenna James Timothy, Christie Michael A, Jeffrey Brianne A, McCoy John G, Lee Eunho, Connolly Nina P, Ward Chris P, Strecker Robert E

Abstract excerpt

Prior research has reported beneficial effects of melatonin in rodent models of Alzheimer's disease (AD). This study evaluated the effect of ramelteon (Rozerem, a melatonin receptor agonist) on spatial learning & memory and neuropathological markers in a transgenic murine model of AD (the B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J transgenic mouse strain; hereafter 'AD mice'). Three months of daily ramelteon treatment...

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Identifiers

PMID: 22786833
DOI: 10.4449/aib.v149i5.1375
PMCID: PMC3872073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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