Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.

doi:10.1210/jcem.84.1.5394

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Article

Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.

The Journal of clinical endocrinology and metabolism - 1 Jan 1999

Liu R Y, Zhou J N, van Heerikhuize J, Hofman M A, Swaab D F

Abstract excerpt

Sleep disruption, nightly restlessness, sundowning, and other circadian disturbances are frequently seen in Alzheimer's disease (AD) patients. Changes in the suprachiasmatic nucleus and pineal gland are thought to be the biological basis for these behavioral disturbances. Melatonin is the main en...

Topics

Aged
Aged, 80 and over
Aging
Alzheimer Disease
Apolipoproteins E
Circadian Rhythm
Female
Genotype
Humans
Male
Melatonin

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