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Article

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls.

Neuroscience letters - 10 May 2002

Schönknecht Peter, Lütjohann Dieter, Pantel Johannes, Bardenheuer Habertus, Hartmann Tobias, von Bergmann Klaus, Beyreuther Konrad, Schröder Johannes

Abstract excerpt

Experiments in cell cultures indicate that accumulation of cholesterol in hippocampal neurons results in an accelerated cleavage of amyloid precursor protein into amyloidogenic components. To be eliminated from the brain, cholesterol is converted to 24S-hydroxycholesterol which may reflect cerebral cholesterol turnover. We investigated cerebrospinal fluid (CSF) concentrations of 24S-hydroxycholesterol in a group...

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Identifiers

PMID: 11983301
DOI: 10.1016/s0304-3940(02)00164-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls.PMID 11983301Read ↗

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