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Mitochondrial Macro-Haplogroup U and Multiple Sclerosis Risk in Arab and Near Eastern Populations: A Pedigree-Anchored Systematic Review and Meta-Analysis

2026-06-28

Abstract excerpt

<title>Abstract</title> <p>Background Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease with incompletely understood aetiology beyond the HLA-DRB1 locus. Mitochondrial haplogroup U prevalent in Middle Eastern and Near Eastern populations encodes functional variants in NADH dehydrogenase subunits associated with elevated reactive oxygen species (ROS) production. A 2022 study (Al-Kafaji et al.,...

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Literature Corpus work
6677e714-0641-5461-8999-3b1dfa81cf33
DOI
10.21203/rs.3.rs-9871924/v1
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