Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility.

PloS one - 6 Aug 2008

Ban Maria, Elson Joanna, Walton Amie, Turnbull Douglas, Compston Alastair, Chinnery Patrick, Sawcer Stephen

Abstract excerpt

Several lines of evidence suggest that mitochondrial genetic factors may influence susceptibility to multiple sclerosis. To explore this hypothesis further, we re-sequenced the mitochondrial genome (mtDNA) from 159 patients with multiple sclerosis and completed a haplogroup analysis including a further 835 patients and 1,506 controls. A trend towards over-representation of super-haplogroup U was the only evidence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex I

Share to Gene Frequency

Share to Genome

Share to Multiple Sclerosis

Share to Reference Values

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 18682780
DOI: 10.1371/journal.pone.0002891
PMCID: PMC2494944

Genes

NDUFS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility.PMID 18682780Read ↗

The role of mitochondrial DNA variants and dysfunction in the pathogenesis and progression of multiple sclerosis.Semantic proximity Read ↗

Mitochondrial DNA sequence variation in multiple sclerosis.Semantic proximity Read ↗

Multiple sclerosis and mitochondrial gene variations: a review.Semantic proximity Read ↗

Next-generation sequencing of the whole mitochondrial genome identifies functionally deleterious mutations in patients with multiple sclerosis.Semantic proximity Read ↗

Mitochondrial complex I gene variations; as a potential genetic risk factor in pathogenesis of multiple sclerosis.Semantic proximity Read ↗

Mitochondrial DNA Variation and Heteroplasmy in Monozygotic Twins Clinically Discordant for Multiple Sclerosis.Semantic proximity Read ↗

[Variability of the Mitochondrial Genome and Development of the Primary Progressing form of Multiple Sclerosis].Semantic proximity Read ↗

Whole mitochondrial DNA variations in hippocampal surgical specimens and blood samples with high-throughput sequencing: a case of mesial temporal lobe epilepsy with hippocampal sclerosis.Semantic proximity Read ↗

[The possibility of using multiple sclerosis-associated variants of the mitochondrial genome to predict the development of multiple sclerosis].Semantic proximity Read ↗

Genetic variants of Complex I in multiple sclerosis.Semantic proximity Read ↗

Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosisSemantic proximity Read ↗

Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.