Article
Genetic contribution to multiple sclerosis risk among Ashkenazi Jews.
BMC medical genetics - 28 Jul 2015
Khankhanian Pouya, Matsushita Takuya, Madireddy Lohith, Lizée Antoine, Din Lennox, Moré Jayaji M, Gourraud Pierre-Antoine, Hauser Stephen L, Baranzini Sergio E, Oksenberg Jorge R
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, with a strong genetic component. Over 100 genetic loci have been implicated in susceptibility to MS in European populations, the most prominent being the 15:01 allele of the HLA-DRB1 gene. The prevalence of MS is high in European populations including those of Ashkenazi origin, and low in African and Asian populations...
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