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Article

Polymorphisms in CLOCK and ARNTL/BMAL-1 genes in multiple sclerosis: a systematic review and meta-analysis.

European journal of medical research - 6 Jan 2026

Oladghaffari Mobina, Bandehagh Heliya, Malekinejad Fatemeh, Fakhkhari Shahrzad, Koohi Narges, Moghaddamziabari Seyedehyasmin, Hamzehzadeh Sina, Mohammadian Elahe, Talebi Mahnaz, Salehi-Pourmehr Hanieh, Naseri Amirreza

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) is still under investigation for its pathogenesis. This study explores the relationship between the key circadian rhythm regulators' genes, ARNTL/BMAL-1 and CLOCK, and MS pathogenesis. METHODS: Following the PRISMA2020 statement, a systematic search was conducted in PubMed, Scopus, Embase, and Web of Science for studies published up to July 2024. Clinical studies concerning the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41495859
DOI: 10.1186/s40001-025-03798-4
PMCID: PMC12870829

Genes

CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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