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Article

Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.

Frontiers in endocrinology - 1 Jan 2024

Dashti Mohammed, Ali Naser M, Alsaleh Hussain, John Sumi Elsa, Nizam Rasheeba, Thanaraj Thangavel Alphonse, Al-Mulla Fahd

Abstract excerpt

Background: Numerous studies have linked mitochondrial dysfunction to the development of type 2 diabetes (T2D) by affecting glucose-stimulated insulin secretion in pancreatic beta cells and reducing oxidative phosphorylation in insulin-responsive tissues. Given the strong genetic underpinnings of T2D, research has explored the connection between mitochondrial DNA haplogroups, specific variants, and the risk and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39659613
DOI: 10.3389/fendo.2024.1443737
PMCID: PMC11628290

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