Back to search

Article

A Drug Screening Platform for Protein Expression Levels in Neurological Disorders

2024-02-28

Abstract excerpt

<h4>Summary</h4> Neurological and psychiatric diseases and disorders affect more than half of the population. Many of these diseases are caused by the malfunctioning of protein synthesis, where too little or too much production of a protein harms a cell and its functions within the brain. We developed a drug screening platform to identify compounds that target the primary cause of these diseases, namely protein e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
66740abb-dd2d-5192-8447-8fa5977c53ca
DOI
10.1101/2024.02.27.582434
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Drug Screening Platform for Protein Expression Levels in Neurological DisordersDOI 10.1101/2024.02.27.582434
The identification of high-performing antibodies for FUS (Uniprot ID: P35637) for use in western blot, immunoprecipitation, immunofluorescence and flow cytometrySemantic proximity
Mapping Protein Numbers in Living CellsSemantic proximity
Genetically encoded fluorescent sensors for visualizing polyamine levels, uptake, and distributionSemantic proximity
A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene SilencingSemantic proximity
High-throughput identification of protein turnover modulators in human neuronsSemantic proximity
A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency.Semantic proximity
Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imagingSemantic proximity
The molecular mechanism of uptake and cell-to-cell transmission of arginine-containing dipeptide repeat proteinsSemantic proximity
Genetically encoded fluorescent reporter for polyaminesSemantic proximity
Small molecule v-ATPase inhibitor Etidronate lowers levels of ALS protein ataxin-2Semantic proximity
A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene SilencingSemantic proximity
Label-Free Cell Phenotypic Assays for Assessing Drug Polypharmacology.Semantic proximity
Select a neighboring publication to make it the new centre.