Article

Genetically encoded fluorescent sensors for visualizing polyamine levels, uptake, and distribution

2024-08-22

Abstract excerpt

<h4>ABSTRACT</h4> Polyamines are abundant and physiologically essential biomolecules that play a role in numerous processes, but are disrupted in diseases such as cancer, and cardiovascular and neurological disorders. Despite their importance, measuring free polyamine concentrations and monitoring their metabolism and uptake in cells in real-time remains impossible due to the lack of appropriate biosensors. Here...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07835b86-add0-5d8c-ad56-3dff222444be
DOI: 10.1101/2024.08.21.609037

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetically encoded fluorescent sensors for visualizing polyamine levels, uptake, and distributionDOI 10.1101/2024.08.21.609037Read

Genetically encoded fluorescent reporter for polyaminesSemantic proximity Read

Polyamines buffer labile iron to suppress ferroptosisSemantic proximity Read

A genetically encoded red fluorescence dopamine biosensor enables dual imaging of dopamine and norepinephrineSemantic proximity Read

Remaining Mysteries of Molecular Biology: The Role of Polyamines in the CellSemantic proximity Read

Structural basis of polyamine transport by human ATP13A2 (PARK9)Semantic proximity Read

Targeting polyamine metabolism for cancer therapy and preventionSemantic proximity Read

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseasesSemantic proximity Read

Ratiometric NAD <sup>+</sup> sensors reveal subcellular NAD <sup>+</sup> modulatorsSemantic proximity Read

Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-methadone for Use in Cells, Organelles, and BiofluidsSemantic proximity Read

A perspective of polyamine metabolismSemantic proximity Read

Fluorescence lifetime imaging of sDarken as a tool for the evaluation of serotonin levelsSemantic proximity Read

ATP13A2 deficiency disrupts lysosomal polyamine export.Semantic proximity Read