Article

Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue

2019-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Decreased expression of the mitochondrial protein frataxin (FXN) causes Friedreich’s ataxia (FRDA). FRDA is a neurodegenerative disease also characterized by systemic metabolic alterations that increase the risk of developing type 2 diabetes thus aggravating FRDA prognosis. Brown adipose tissue (BAT) is a mitochondria-enriched and anti-diabetic tissue that, in addition to its thermoregulatory ro...

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Literature Corpus work: 33556b4c-9c03-5fcb-bc1b-20cc632f1c2c
DOI: 10.1101/664649

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