Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo.

Journal of lipid research - 1 Sept 2018

Kim Jihyun, Park Min Sung, Ha Kyoungsoo, Park Chulhong, Lee Jisu, Mynatt Randall L, Chang Ji Suk

Abstract excerpt

Transcriptional coactivator PPAR γ coactivator (PGC)-1α and its splice variant N-terminal (NT)-PGC-1α mediate transcriptional regulation of brown adipose tissue (BAT) thermogenesis in response to changes in ambient temperature. PGC-1α is dispensable for cold-induced BAT thermogenesis as long as NT-PGC-1α is present. However, the functional significance of NT-PGC-1α in BAT has not been determined. In the present...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue, Brown
Share to Adipose Tissue, White

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Acids

Share to Lipolysis

Share to Mitochondria

Share to Oxidation-Reduction

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Thermogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 30026188
DOI: 10.1194/jlr.M085647
PMCID: PMC6121938

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo.PMID 30026188Read ↗

Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolismSemantic proximity Read ↗

An emerging role for epigenetic regulation of Pgc-1α expression in environmentally stimulated brown adipose thermogenesisSemantic proximity Read ↗

PGC-1 coactivators in the control of energy metabolismSemantic proximity Read ↗

Loss of the alternative calcineurin variant CnAβ1 enhances brown adipocyte differentiation and drives metabolic overactivation through FoxO1 activationSemantic proximity Read ↗

Negative Regulators of Brown Adipose Tissue (BAT)‐Mediated ThermogenesisSemantic proximity Read ↗

Cold tolerance, cold-induced hyperphagia, and nonshivering thermogenesis are normal in α₁-AMPK-/- mice.Semantic proximity Read ↗

Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stressSemantic proximity Read ↗

Blossoming 20: The Energetic Regulator's Birthday Unveils its Versatility in Cardiac DiseasesSemantic proximity Read ↗

Mitochondrial biogenesis and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity: intact adipocytokine signaling is required.Semantic proximity Read ↗

Nipsnap1—A Regulatory Factor Required For Long-Term Maintenance of Non-Shivering ThermogenesisSemantic proximity Read ↗

Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose BrowningSemantic proximity Read ↗

Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissueSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.