Article

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

2023-03-23

Abstract excerpt

The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of adipocyte stem and progenitor cells (ASPCs) and adipocytes during the beiging process. We found that aging increases the expression of Cd9 and other fibro-inflammatory genes in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d602d10-80c8-5542-8d27-b9b33220cf12
DOI: 10.1101/2023.03.20.533514

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogrammingDOI 10.1101/2023.03.20.533514Read

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogrammingSemantic proximity Read

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogrammingSemantic proximity Read

Shifts of Immune Cell Populations Differ in Response to Different Effectors of Beige Remodeling of Adipose TissueSemantic proximity Read

Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA SequencingSemantic proximity Read

Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans.Semantic proximity Read

Cellular Origins of Beige Fat Cells RevisitedSemantic proximity Read

Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis.Semantic proximity Read

Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging processSemantic proximity Read

Single-cell transcriptomic analysis reveals dynamic activation of cellular signaling pathways regulating beige adipogenesisSemantic proximity Read

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathwaySemantic proximity Read

Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibilitySemantic proximity Read

Multidimensional Single-Nuclei RNA-Seq Reconstruction of Adipose Tissue Reveals Adipocyte Plasticity Underlying Thermogenic ResponseSemantic proximity Read