Article

Intra-Nuclear Tensile Strain Mediates Reorganization of Epigenetically Marked Chromatin During Cardiac Development and Disease

2018-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Environmental mechanical cues are critical to guide cell fate. Forces transmit to the nucleus through the Linker of Nucleo- and Cytoskeleton (LINC) complex and are thought to influence the organization of chromatin that is related to cell differentiation; however, the underlying mechanisms are unclear. Here, we investigated chromatin reorganization during murine cardiac development and found tha...

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Literature Corpus work: 1bebe768-ac78-58e5-8d85-d0abed9f0b2a
DOI: 10.1101/455600

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