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Article

Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease

2024-02-21

Abstract excerpt

<h4>Background</h4> Clonal hematopoiesis of indeterminate potential (CHIP) increases risk of cardiovascular disease yet the molecular mechanisms driving this association remain incompletely understood. We hypothesized that aberrant monocyte-endothelial interactions contribute to CHIP-mediated cardiovascular disease. <h4>Methods</h4> We performed single-cell RNA sequencing on blood and peripheral vascular tissue...

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Literature Corpus work
5722709b-036e-5819-bb28-1be2aa4b6cac
DOI
10.1101/2024.02.20.24303046
Open publication

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Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular diseaseDOI 10.1101/2024.02.20.24303046
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