Article
CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study.
Circulation - 23 Aug 2005
McDermott David H, Yang Qiong, Kathiresan Sekar, Cupples L Adrienne, Massaro Joseph M, Keaney John F, Larson Martin G, Vasan Ramachandran S, Hirschhorn Joel N, O'Donnell Christopher J, Murphy Philip M, Benjamin Emelia J
Abstract excerpt
BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory. METHODS AND RESULTS: We analyzed the association of genetic variation in the MCP-1 gene (CCL2) with prevalent myocardial infarction and serum MCP-1 levels in the community-based Framingham Heart Study Offspring Cohort (50% women; mean...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.