Article
Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits.
Circulation. Cardiovascular genetics - 1 Jun 2016
Golbus Jessica R, Stitziel Nathan O, Zhao Wei, Xue Chenyi, Farrall Martin, McPherson Ruth, Erdmann Jeanette, Deloukas Panos, Watkins Hugh, Schunkert Heribert, Samani Nilesh J, Saleheen Danish, Kathiresan Sekar, Reilly Muredach P
Abstract excerpt
BACKGROUND: The chemokine receptors CCR2, CCR5, and CX3CR1 coordinate monocyte trafficking in homeostatic and inflammatory states. Multiple small human genetic studies have variably linked single nucleotide polymorphisms in these genes to cardiometabolic disease. We interrogated genome-wide association, exome sequencing, and exome array genotyping studies to ascertain the relationship between variation in these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.