Article
Role of the fractalkine receptor CX3CR1 polymorphisms V249I and T280M as risk factors for early-onset coronary artery disease in patients with no classic risk factors.
Scandinavian journal of clinical and laboratory investigation - 1 Jan 2008
Nassar B A, Nanji A A, Ransom T P, Rockwood K, Kirkland S A, Macpherson K, Connelly P W, Johnstone D E, O'Neill B J, Bata I R, Andreou P, Title L M
Abstract excerpt
OBJECTIVES: CX3CR1 is a monocyte chemokine receptor and adhesion molecule. Two CX3CR1 mutations, V249I and T280M, reportedly decrease coronary artery disease (CAD) risk independent of established risk factors. An I249 protective effect is attributed to reducing CX3CR1 binding to fractalkine, its ligand. MATERIAL AND METHODS: We examined the frequencies of V249I and T280M among early-onset CAD patients (G1; n =...
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