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Article

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease.

Nucleic acids research - 6 Sept 2018

Timmons James A, Atherton Philip J, Larsson Ola, Sood Sanjana, Blokhin Ilya O, Brogan Robert J, Volmar Claude-Henry, Josse Andrea R, Slentz Cris, Wahlestedt Claes, Phillips Stuart M, Phillips Bethan E, Gallagher Iain J, Kraus William E

Abstract excerpt

Genome-wide association studies (GWAS), relying on hundreds of thousands of individuals, have revealed >200 genomic loci linked to metabolic disease (MD). Loss of insulin sensitivity (IS) is a key component of MD and we hypothesized that discovery of a robust IS transcriptome would help reveal the underlying genomic structure of MD. Using 1,012 human skeletal muscle samples, detailed physiology and a...

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Source

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Identifiers

PMID: 29986096
DOI: 10.1093/nar/gky570
PMCID: PMC6125682

Genes

AGL
DHTKD1
ECHDC3
KPNA2
MCCC1
OARD1
PCYT2
PGM2
PRRX1
RND3
SGCG
SMIM8
TSPAN9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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