Article

Exon-Skipping Antisense Oligonucleotides for H3.3K27M-Altered Diffuse Midline Glioma Therapy

2026-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Diffuse midline gliomas (DMGs) are a deadly class of pediatric high-grade brain cancers. Approximately 80% of pontine DMGs feature a dominant, somatic, heterozygous point mutation in the non-canonical histone H3.3-coding gene H3-3A . This dominant-negative mutation replaces lysine 27 with methionine (K27M) and prevents global K27 di- and tri-methylation of all wild-type histone H3 proteins. We...

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Literature Corpus work: 660b3d19-bf04-524a-8d57-088128dec6c1
DOI: 10.64898/2026.04.03.715131

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