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Article

Interplay between nucleoid-associated proteins and transcription factors in controlling specialized metabolism in <i>Streptomyces</i>

2021-04-16

Abstract excerpt

<h4>ABSTRACT</h4> Lsr2 is a small nucleoid-associated protein found throughout the actinobacteria. Lsr2 functions similarly to the well-studied H-NS, in that it preferentially binds AT-rich sequences and represses gene expression. In Streptomyces venezuelae , Lsr2 represses the expression of many specialized metabolic clusters, including the chloramphenicol antibiotic biosynthetic gene cluster, and deleting lsr...

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Literature Corpus work
f473fc03-b4e3-534c-8568-279725140e6c
DOI
10.1101/2021.04.15.440093
Open publication

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Interplay between nucleoid-associated proteins and transcription factors in controlling specialized metabolism in <i>Streptomyces</i>DOI 10.1101/2021.04.15.440093
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