Article

Modelling Amoebic Brain Infection Caused by <i>Balamuthia mandrillaris</i> Using a Human Cerebral Organoid

2024-04-08

Abstract excerpt

The lack of disease models adequately resembling human tissue has hindered our understanding of amoebic brain infection. Three-dimensional structured organoids provide a microenvironment similar to human tissue. This study demonstrates the use of cerebral organoids to model a rare brain infection caused by the highly lethal amoeba Balamuthia mandrillaris . Cerebral organoids were generated from human pluripotent...

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Literature Corpus work: f5e628e2-2faf-5307-99b8-40baf0d80794
DOI: 10.1101/2024.04.06.588187

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