Article

Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria

2024-06-04

Abstract excerpt

Nitroxoline is a bacteriostatic quinoline antibiotic, considered a metal chelator inhibiting the activity of RNA-polymerase 1 . Its clinical indications are limited to uncomplicated urinary tract infections (UTIs), with a clinical susceptibility breakpoint only available for Escherichia coli 2 . By testing > 1,000 clinical isolates, here we demonstrate a much broader activity spectrum and species-specific bacter...

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Literature Corpus work: 03f5e9d8-ff9c-562e-8e18-ff2fbd753bb3
DOI: 10.1101/2024.06.04.597298

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