Article

Identification of Injury-Response State Determinants in Glioblastoma Stem Cells

2025-04-12

Abstract excerpt

Glioblastoma (GBM) is a common and highly lethal type of primary brain tumor in adults. Therapeutic failure is partly attributed to a fraction of Glioblastoma Stem Cells (GSCs) that show high levels of heterogeneity and plasticity. GSCs exist in a transcriptional gradient between two states: Developmental (Dev) and Injury Response (IR) in which IR-GSCs exhibit more invasive behaviors. While previous studies have i...

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Literature Corpus work: d1d5d91d-e227-56e9-8354-d634de23020c
DOI: 10.1101/2025.04.07.647626

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