Article

Impact of genomic background and developmental state on signaling pathways and response to therapy in glioblastoma patient-derived cells

2024-03-16

Abstract excerpt

Glioblastoma (GBM) tumors represents diverse genomic epigenomic, and transcriptional landscapes, with significant intratumoral heterogeneity that challenges standard of care treatments involving radiation (RT) and the DNA-alkylating agent temozolomide (TMZ). In this study, we employed targeted proteomics to assess the response of a genomically-diverse panel of GBM patient-derived cancer stem cells (CSCs) to astroc...

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Literature Corpus work: 5a576ca1-e709-51ce-a14d-474691f891bb
DOI: 10.1101/2024.03.14.585115

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