Article

Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy

2023-10-10

Abstract excerpt

The rational combination of anticancer agents is critical to improving patient outcomes in cancer. Nonetheless, most combination regimens in the clinic result from empirical methodologies disregarding insight into the mechanism of action and missing the opportunity to improve therapy outcomes incrementally. Deciphering the genetic dependencies and vulnerabilities responsible for synergistic interactions is crucial...

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Literature Corpus work: f32df868-7ffa-53ff-b159-66b3a71fee27
DOI: 10.1101/2023.10.07.561351

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