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Article

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson's Disease: Comparative Analysis of G2019S and I1371V Variants.

Cells - 13 Feb 2026

Singh Khushboo, Banerjee Roon, Potdar Chandrakanta, Shaw Anisha, Rakshith Rakshith, Kamble Nitish, Holla Vikram, Yadav Ravi, Pal Pramod Kumar, Datta Indrani

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson's disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 differentially perturb cellular homeostasis remains incompletely understood. Here, we compared two pathogenic LRRK2 mutations-G2019S in the kinase domain and I1371V in the GTPase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41744785
DOI: 10.3390/cells15040342
PMCID: PMC12939846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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