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Systematic profiling of WD40 proteins reveals Wcp1, a cyclophilin linking CO <sub>2</sub> /heat tolerance to acidic pH adaptation in <i>Cryptococcus neoformans</i>

2026-05-15

Abstract excerpt

WD40 domains are major protein–protein interaction (PPI) scaffolds, yet their contributions to fungal pathogenicity remain poorly defined. We systematically analysed 94 canonical WD40 proteins in Cryptococcus neoformans . Conditional knockdown and sporulation identified 36 essential WD40 proteins, while in vitro and in vivo profiling of 103 signature-tagged deletion strains spanning 52 genes uncovered 31 pathogen...

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Literature Corpus work
654b6042-5b08-52e0-b312-4a4a771353b4
DOI
10.64898/2026.05.15.725558
Open publication

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Systematic profiling of WD40 proteins reveals Wcp1, a cyclophilin linking CO <sub>2</sub> /heat tolerance to acidic pH adaptation in <i>Cryptococcus neoformans</i>DOI 10.64898/2026.05.15.725558
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