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Pleiotropic Roles of the Msi1-Like Protein Msl1 in Cryptococcus neoformans

6 Oct 2012

Abstract excerpt

Msi1-like (MSIL) proteins contain WD40 motifs and have a pleiotropic cellular function as negative regulators of the Ras/cyclic AMP (cAMP) pathway and components of chromatin assembly factor 1 (CAF-1), yet they have not been studied in fungal pathogens. Here we identified and characterized an MSIL protein, Msl1, in Cryptococcus neoformans, which causes life-threatening meningoencephalitis in humans. Notably, Msl1...

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PMID: 23042129
DOI: 10.1128/ec.00261-12

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