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The RAM signaling pathway links morphology, thermotolerance, and CO <sub>2</sub> tolerance in the global fungal pathogen <i>Cryptococcus neoformans</i>

2022-08-14

Abstract excerpt

The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each year. Survival of this basidiomycete at host CO 2 concentrations has only recently been considered an important virulence trait. Through screening gene knockout libraries constructed in a CO 2 -tolerant clinical strain, we found mutations leading to CO 2 sensitivity are enriched in pathways activated by heat stress, including cal...

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Literature Corpus work
f6dffe9b-7311-551e-9a82-ad6374f885ab
DOI
10.1101/2022.08.14.503895
Open publication

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The RAM signaling pathway links morphology, thermotolerance, and CO <sub>2</sub> tolerance in the global fungal pathogen <i>Cryptococcus neoformans</i>DOI 10.1101/2022.08.14.503895
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