Article
Transcription factor Liv4 is required for growth and pathogenesis of Cryptococcus neoformans.
FEMS yeast research - 1 May 2020
Yi Jiu, Sang Junjun, Zhao Jingyu, Gao Lei, Yang Yali, Yan Lei, Zhang Chao, Pan Weihua, Wang Guizhen, Liao Wanqing
Abstract excerpt
Cryptococcus neoformans is an important invasive fungal pathogen that causes life-threatening meningoencephalitis in humans. Its biological and pathogenic regulatory mechanisms remain largely unknown, particularly due to the presence of those core transcription factors (TFs). Here, we conducted a detailed characterization of the TF Liv4 in the biology and virulence of C. neoformans. Deletion of TF Liv4 protein...
Topics
- Animals
- Cryptococcosis
- Cryptococcus neoformans
- Female
- Fungal Proteins
- Gene Expression Profiling
- Gene Expression Regulation, Fungal
- Macrophages
- Mice
- Mice, Inbred BALB C
- Phenotype