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Systematic profiling of WD40 proteins reveals Wcp1, a cyclophilin linking CO2/heat tolerance to acidic pH adaptation in Cryptococcus neoformans

2026-06-10

Abstract excerpt

<title>Abstract</title> <p> WD40 domains are major protein–protein interaction (PPI) scaffolds, yet their contributions to fungal pathogenicity remain poorly defined. We systematically analysed 94 canonical WD40 proteins in <italic>Cryptococcus neoformans</italic> . Conditional knockdown and sporulation identified 36 essential WD40 proteins, while in vitro and in vivo profiling of 103 signature-tagged deletion...

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Literature Corpus work
be3fa941-3525-58c9-b817-1c331602a136
DOI
10.21203/rs.3.rs-9899291/v1
Open publication

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Systematic profiling of WD40 proteins reveals Wcp1, a cyclophilin linking CO2/heat tolerance to acidic pH adaptation in Cryptococcus neoformansDOI 10.21203/rs.3.rs-9899291/v1
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