Article
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells
2019-04-15
Abstract excerpt
<h4>ABSTRACT</h4> Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants for each were generated in non-transformed MCF10A mammary epithelial cells and in transformed U2OS and HEK293 cells. In U2OS and HEK293 cells, viable ablated clones were readi...
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Identifiers and source
- Literature Corpus work
- 64f913f6-7b31-58da-8a0a-1896817b84b6
- DOI
- 10.1101/609115