Article
Cancer mutations in RAD51 and its paralogues.
PloS one - 1 Jan 2026
Valentine Anna L, Huth Isabella L, Duff Nika M, Rabbani Aisha Z, Donahue Kateri N, Bush Wesley A, Bouley Renee A, Petreaca Ruben C
Abstract excerpt
The RAD51 recombinase is central to repair of DNA damage arising from stalled or collapsed replication forks and DNA double strand breaks. Its essential role is revealed by the fact that this function evolved in bacteria but was retained in eukaryotes. In humans some of the RAD51 functions have been relegated to several paralogues which evolved by gene duplication. In addition to mutations, most cancers are also...
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