Article

Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy Targets

2019-11-13

Abstract excerpt

This study was aimed to investigate the mutations in colorectal cancer (CRC) for recurrent neoantigen identification. A total of 1,779 samples with whole exome sequencing (WES) data were obtained from 7 published CRC cohorts. Common HLA genotypes were used to predict the probability of neoantigens at high frequency mutants in the dataset. Based on the WES data, we not only obtained the most comprehensive CRC mutat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64dbc294-2110-55b3-b072-5b1f8dddac72
DOI: 10.1101/840918

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy TargetsDOI 10.1101/840918Read

Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy Targets.Semantic proximity Read

The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenicSemantic proximity Read

[A method of screening highly common neoantigens with immunogenicity in colorectal cancer based on public somatic mutation library].Semantic proximity Read

Neoantigens Derived from Recurrently Mutated Genes as Potential Immunotherapy Targets for Gastric CancerSemantic proximity Read

Evolving neoantigen profiles in colorectal cancers with DNA repair defectsSemantic proximity Read

Immunogenicity of Neoantigens in Colorectal Cancer: Potential Influence of Tumor Mutation Burden, Stages, and MetastasisSemantic proximity Read

Mutated genes on ctDNA detecting postoperative recurrence presented reduced neoantigens in primary tumors in colorectal cancer cases.Semantic proximity Read

A Comprehensive Survey of Mutations in Oesophageal Carcinoma Reveals Recurrent Neoantigens as Potential Immunotherapy TargetsSemantic proximity Read

Evolving neoantigen profiles in colorectal cancers with DNA repair defectsSemantic proximity Read

Identification of public neoantigens with broad HLA class I coverage as candidates for off-the-shelf cancer vaccine development in colorectal cancer.Semantic proximity Read

A Comprehensive Survey of Genomic Alterations in Gastric Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.Semantic proximity Read

Whole-Exome Sequencing to Screen Personal Neoantigens With High Immunogenicity in Patients With Microsatellite Stability (MSS)-Advanced Colorectal Cancer.Semantic proximity Read