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Article

Identification of public neoantigens with broad HLA class I coverage as candidates for off-the-shelf cancer vaccine development in colorectal cancer.

Frontiers in immunology - 1 Jan 2026

Tran Diem Tp, Nguyen Bui Que Tran, Nguyen Huu Thinh, Pham Thi Mong Quynh, Nguyen Dinh Viet Linh, Nguyen Thanh Nhan, Ho Thi Kim Cuong, Nguyen Vy, Nguyen Pham Trung Dung, Tran Duc Huy, Tran Thanh Sang, Pham Truong-Vinh Ngoc, Le Minh-Triet, Giang Hoa, Nguyen Hoai Nghia, Phan Minh-Duy, Tran Le Son

Abstract excerpt

Introduction: Shared neoantigens derived from recurrent mutations represent promising targets for off-the-shelf (OTS) cancer immunotherapies; however, their clinical utility is often constrained by population-specific HLA diversity and variable immunogenicity. There remains a need for population-tailored neoantigen panels with broad HLA coverage and functional validation. Methods: We developed a colorectal cancer...

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Share to Antigens, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41789101
DOI: 10.3389/fimmu.2026.1686224
PMCID: PMC12957132

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