Article
[A method of screening highly common neoantigens with immunogenicity in colorectal cancer based on public somatic mutation library].
Yi chuan = Hereditas - 20 Jun 2020
Qin Li Li, Li Yi Jian, Liang Zhao Rui, Dai Lei, Li Wen Hui, Chen Chao, Huang Ya Ling, Zhang Le, Liu Song Ming, Qiu Si, Ge Yu Ping, Peng Wen Ting, Lin Xin Xin, Zhang Xiu Qing, Dong Xuan, Li Bo
Abstract excerpt
Colorectal cancer (CRC) is a malignant cancer with high incidence and mortality in the world. Immunotherapy targeting neoantigens can induce durable tumor regression in cancer patients, but is almost limited to personalized precision therapy, due to the individual differences of unique neoantigens. With the discovery of many common oncogenic mutations, and such mutation-associated neoantigens could cover more...
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