Article
A Comprehensive Survey of Genomic Alterations in Gastric Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.
BioMed research international - 1 Jan 2019
Chen Chao, Zhou Qiming, Wu Riping, Li Bo, Chen Qiang, Zhang Xiuqing, Shi Chunmei
Abstract excerpt
Immunotherapy directed against cancer-specific neoantigens derived from non-silent mutants is a promising individualized strategy for cancer treatment. Neoantigens shared across patients could be used as a public resource for developing T cell-based therapy. To identify potential public neoantigens for therapy in gastric cancer (GC), 74 GC patients were enrolled in this study. Combined with the TCGA cohort and...
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