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Article

Mutated genes on ctDNA detecting postoperative recurrence presented reduced neoantigens in primary tumors in colorectal cancer cases.

Scientific reports - 24 Jan 2023

Nagayama Satoshi, Kobayashi Yuta, Fukunaga Mitsuko, Sakimura Shotaro, Sugimachi Keishi, Sasaki Shin, Masuda Takaaki, Mafune Ken-Ichi, Oshima Masanobu, Shibata Tatsuhiro, Suzuki Yutaka, Mimori Koshi

Abstract excerpt

The detection and sequencing of the mutated ctDNA is one of the irreplaceable clinical measures in the postoperative management of colorectal cancer (CRC) cases. However, we are curious to comprehend the essential traits of mutated genes comprising metastatic sites out of whole mutated genes in primary sites. In the current retrospective study, we conducted target resequencing of ctDNA using 47 plasma samples and...

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Identifiers

PMID: 36693917
DOI: 10.1038/s41598-023-28575-3
PMCID: PMC9873919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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