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Article

Whole-Exome Sequencing to Screen Personal Neoantigens With High Immunogenicity in Patients With Microsatellite Stability (MSS)-Advanced Colorectal Cancer.

Human mutation - 1 Jan 2026

Li Dajiang, Shen Wenjing, Yang Siyu, Liu Hongmei, Tan Xiao, He Xinrong, Hao Jingchao, Yin Xinqiang

Abstract excerpt

To develop a personalized neoantigen therapy strategy for microsatellite stability (MSS)-advanced colorectal cancer (CRC), neoantigens from collected human CRC samples were screened, and the feasibility and effectiveness of these neoantigens in treating CRC were explored. Whole-exome sequencing and transcriptome sequencing were performed to identify somatic mutations, RNA expression, and human leukocyte antigen...

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Share to Antigens, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42087894
DOI: 10.1155/humu/3876230
PMCID: PMC13136688

Genes

CDH4
ZNF169
MAP3K9
NIM1K
SOX9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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