Article

Study of interaction energies between residues of the active site of Hsp90 and geldanamycin analogues using quantum mechanics/molecular mechanics methods

2020-04-16

Abstract excerpt

<h4>Background: </h4> Heat shock protein (Hsp90KDa) is a molecular chaperone involved in the process of cellular oncogenesis, hence its importance as a therapeutic target. Geldanamycin is an inhibitor of Hsp90 chaperone activity, which binds to the ATP binding site in the N-terminal domain of Hsp90. However, geldanamycin has shown hepatotoxic damage in clinical trials; for this reason, its use is not recommended....

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Literature Corpus work: 64bd08d3-5aeb-59c0-8a3e-c0b6cfada4c0
DOI: 10.12688/f1000research.20844.2

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