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Article

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.

Journal of molecular biology - 14 Sept 2007

Onuoha S C, Mukund S R, Coulstock E T, Sengerovà B, Shaw J, McLaughlin S H, Jackson S E

Abstract excerpt

Heat shock protein 90 (Hsp90) is a molecular chaperone that is required for the maturation and activation of a number of client proteins, many of which are involved in cancer development. The ansamycin family of natural products and their derivatives, such as geldanamycin (GA), are well-known inh...

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Source

Identifiers

PMID: 17662999
DOI: 10.1016/j.jmb.2007.06.065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17662999-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.PMID 17662999Read ↗

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