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Analyzing interaction of rhodacyanine inhibitor ‘MKT-077’ with <i>Plasmodium falciparum</i> HSP70 nucleotide binding domains

2023-07-29

Abstract excerpt

MKT-077 and its derivatives are rhodacyanine inhibitors that hold potential in treatment of cancer, neurodegenerative diseases and malaria. These allosteric drugs act by inhibiting the ATPase action of heat shock proteins of 70kDa (HSP70). MKT-077 accumulates in the mitochondria and displays differential activity against HSP70 homologs. The four Plasmodium falciparum HSP70s (PfHSP70) are present at various subcel...

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Literature Corpus work
0d703f53-a73d-5b2c-9df8-35e4a3065f3c
DOI
10.1101/2023.07.27.550796
Open publication

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Analyzing interaction of rhodacyanine inhibitor ‘MKT-077’ with <i>Plasmodium falciparum</i> HSP70 nucleotide binding domainsDOI 10.1101/2023.07.27.550796
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