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Natural Product Origins of Hsp90 Inhibitors

1 Oct 2003

Abstract excerpt

The currently used Hsp90 inhibitors, geldanamycin, herbimycin A and radicicol, were isolated many years ago from Streptomyces and fungi originally for their antiprotozoal activity, herbicidal activity and antifungal activity, respectively. In the mid 1980s, it was found that the benzoquinone ansamycin antibiotics (herbimycin A, geldanamycin, and macbecin) reversed v-Src transformed cells to normal phenotypes, and...

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PMID: 14529384
DOI: 10.2174/1568009033481796

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