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Article

Geldanamycin and its derivatives as Hsp90 inhibitors.

Frontiers in bioscience (Landmark edition) - 1 Jun 2012

Gorska Magdalena, Popowska Urszula, Sielicka-Dudzin Alicja, Kuban-Jankowska Alicja, Sawczuk Wojciech, Knap Narcyz, Cicero Giuseppe, Wozniak Fabio

Abstract excerpt

The Hsp90 molecule, one of the most abundant heat shock proteins in mammalian cells, maintains homeostasis and prevents stress-induced cellular damage. Hsp90 is expressed under normal conditions at a level of about 1-2 Percent of total proteins, while its expression increases 2-10 fold in cancer cells. The two main constitutively expressed isoforms of Hsp90 are known as Hsp90-alpha and Hsp90-beta, and their...

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PMID: 22652777
DOI: 10.2741/4050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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