Article
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin.
Cancer chemotherapy and pharmacology - 1 Jan 1998
Schulte T W, Neckers L M
Abstract excerpt
PURPOSE: Benzoquinone ansamycins are antibiotics with anticancer potential. First described as tyrosine kinase inhibitors, they are now frequently used to target HSP90 chaperone function. While herbimycin A and geldanamycin (GA) have been widely used in preclinical studies, both drugs are poor ca...
Topics
- 3T3 Cells
- Animals
- Antibiotics, Antineoplastic
- Benzoquinones
- Cell Division
- Enzyme Inhibitors
- Female
- HSP90 Heat-Shock Proteins
- Humans
- Lactams, Macrocyclic
- Mice
- Mutation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins c-raf
- Quinones
- Receptor, ErbB-2
- Rifabutin
- Tumor Cells, Cultured