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Article

Rational Biosynthetic Engineering for Optimization of Geldanamycin Analogues

23 Mar 2009

Abstract excerpt

Tailor made: We report the rational biosynthesis of C15 hydroxylated non-quinone geldanamycin analogues by site-directed mutagenesis of the geldanamycin polyketide synthase (PKS), together with a combination of post-PKS tailoring genes. Rational biosynthetic engineering allowed the generation of geldanamycin derivatives, such as DHQ3 illustrated in the figure, which had superior pharmacological properties in...

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PMID: 19308924
DOI: 10.1002/cbic.200800763

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